Ai întrebări despre autism, ADHD, anxietate sau depresie? Găsești ghiduri clare, verificate de specialiști. Acum, acces gratuit.
Research demonstrates that hundreds of genetically diverse causes of autism dysfunction converge on common molecular pathways during early brain development. This finding suggests potential shared therapeutic targets despite the genetic heterogeneity of autism spectrum disorder.
This study evaluated the psychometric properties of the DASS-10 in 354 treatment-seeking adults with mild TBI, finding good fit to the Rasch model with high internal consistency and acceptable unidimensionality. Results support the DASS-10 as a reliable, brief screening tool for psychological distress in post-mild TBI outpatient populations.
Alzheimer's disease and epilepsy frequently co-occur and share common pathogenic mechanisms involving AMPA-type glutamate receptors. Perampanel, an FDA-approved AMPAR antagonist for seizure management, may offer therapeutic benefits in patients with comorbid AD-epilepsy, particularly those with myoclonus or sleep disturbances, though clinical evidence remains limited.
A case of a middle-aged woman with well-controlled epilepsy who presented with persistent anxiety, depression, and irritability despite adequate psychiatric medication (escitalopram, olanzapine). Investigation revealed temporal lobe epilepsy auras as the underlying cause, and adjustment of anti-seizure therapy with lacosamide resulted in complete symptom resolution and significant functional improvement.
This prospective study of 476 traumatic spinal cord injury patients found that 47% also had concomitant traumatic brain injury, with 85% being mild cases. Risk factors for co-occurring injuries included history of substance abuse, motor vehicle accidents, high-energy mechanisms, and tetraplegia rather than paraplegia.
