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This Norwegian registry study tracked over 229,000 incident stroke cases across 20 years, finding overall declining stroke incidence in both sexes, though ischemic stroke increased 1.6% annually in men under 35 years old. Transient ischemic attack incidence rose sharply until 2012 then declined substantially thereafter.
This narrative review examines why anticoagulation fails in some patients with patent foramen ovale (PFO)-related cryptogenic stroke, synthesizing evidence showing transcatheter closure is superior to medical therapy in appropriately selected patients. The analysis incorporates pathophysiological mechanisms, randomized trial comparisons, and risk stratification tools (RoPE score, PASCAL classification) to guide optimal therapeutic selection.
This cohort study of 2,266 stroke/TIA patients found that poor pre-stroke subjective sleep quality (highest PSQI quartile) significantly increased 1-year mortality risk (3.73-fold) and poor functional outcome risk (2.15-fold) compared to good sleep quality. The association remained independent after adjusting for confounders, suggesting sleep quality as a prognostic marker in acute ischemic stroke.
This study of 406 acute ischemic stroke/TIA patients found that atrial fibrillation combined with high cervicocerebral atherosclerotic burden significantly increased 7-year mortality risk, with those having AF and high atherosclerosis burden facing approximately 3-fold greater mortality risk. The findings suggest that concurrent presence of these two vascular conditions substantially worsens long-term outcomes compared to either condition alone.
This is an expression of concern (editorial notice) regarding a previously published case series linking ischemic stroke and transient ischemic attack to large-vessel vasculitis complications of primary Sjögren's syndrome. The concern document does not appear to endorse or dispute the clinical relationship itself, but rather raises methodological or publication integrity questions about the original article.