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A systematic review of 14 human studies (1994–2023) examined deep brain stimulation (DBS) targeting three brain regions to slow cognitive decline in Alzheimer disease. The fornix and nucleus basalis of Meynert showed promise in slowing decline according to standardized cognitive scales, though sample sizes were modest and long-term efficacy remains to be established.
This study analyzes how major US newspapers portrayed disease-modifying treatments (DMTs) for Alzheimer's disease between 2020-2024, finding that media coverage linked treatment risks primarily to efficacy-to-cost ratios. The research identifies tensions between FDA regulatory challenges, expert disagreement over evidence quality, and patient expectations regarding these novel therapies.
This systematic review and meta-analysis examined the effects of virtual reality interventions on cognitive function in people with Alzheimer's disease across three randomized controlled trials involving 75 participants. VR showed modest improvements in memory performance compared to usual treatment, but demonstrated little to no effect on executive function.
This review examines neuropsychiatric symptoms (NPS) across four major dementia syndromes—Alzheimer's disease, vascular dementia, Lewy body dementia, and frontotemporal dementia—highlighting that these symptoms often emerge early or even precede cognitive decline. The article provides clinical guidance for primary care teams to recognize prodromal neurodegenerative disease and initiate appropriate diagnostic workup, addressing gaps in dementia training among frontline practitioners.
Recent observational studies suggest the Mediterranean diet may be associated with reduced cognitive decline and lower Alzheimer's disease risk, possibly through vascular, metabolic, and anti-inflammatory mechanisms. However, causality has not been established, and large-scale randomized controlled trials are needed to confirm whether the diet can serve as a preventive strategy for dementia.