Hypertension and Dementia: Pathophysiology and Potential Utility of Antihypertensives in Reducing Disease Burden
This review examines hypertension as a modifiable risk factor for dementia, finding that mid-life hypertension (ages 45-64) correlates with increased cognitive decline and dementia risk, while late-life hypertension shows less consistent associations. Evidence on whether antihypertensive treatment effectively prevents dementia remains conflicting across studies, likely due to methodological differences between observational and randomized controlled trials.