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StudiuDemențeÎncredere înaltă22.06.2026

Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease

This study examined how cognitive reserve—the brain's ability to maintain function despite Alzheimer's pathology—differs between typical and limbic-predominant subtypes of Alzheimer's disease using neuroimaging data from over 500 participants. Results showed that higher cognitive reserve predicted slower cognitive decline, with typical Alzheimer's subtype showing faster reserve deterioration than the limbic-predominant form, highlighting the importance of subtype-specific analyses in understanding disease progression.

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Expert Consensus on Amyloid-PET Imaging for Alzheimer's Disease Diagnosis

This expert consensus addresses the clinical application of amyloid positron emission tomography (PET) as a standardized tool for early detection of Alzheimer's disease pathology, which precedes cognitive symptoms. The document recommends binary interpretation (positive/negative) of amyloid-PET results combined with clinical assessment, neuropsychological testing, and other imaging biomarkers for reliable diagnosis and treatment evaluation.

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German UCSF Brain Health Assessment Shows High Sensitivity for Early Neurodegenerative Disorders

A validation study of the tablet-based UCSF Brain Health Assessment (BHA) and Brain Health Survey (BHS) in German-speaking patients found these tools highly accurate at detecting mild neurocognitive disorder and non-Alzheimer's presentations, with greater sensitivity than the Montreal Cognitive Assessment. The combined instrument achieved 95% accuracy for mild neurocognitive disorder and 96% accuracy for non-amyloid pathology cases, suggesting potential for earlier identification in primary care settings.

StudiuDemențeÎncredere înaltă22.06.2026

Anticholinergic Deprescribing Interventions for Reducing Cognitive Decline or Dementia Risk in Older Adults

This systematic review examines whether reducing anticholinergic medication burden through deprescribing interventions can prevent or slow cognitive decline in older adults. The review compares effectiveness of different deprescribing approaches (pharmacist-led, physician-led, educational) and evaluates optimal intervention duration and sustainability for maintaining cognitive health.

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Animal-Assisted Therapy for Well-being in Alzheimer's Disease: The ELIAUT Randomized Controlled Trial

A single-blind RCT in 42 Alzheimer's patients compared animal-assisted therapy combined with cognitive stimulation versus cognitive stimulation alone. Animal-assisted therapy produced a statistically significant improvement in immediate well-being after four weeks, but did not affect cognitive function, behavioral symptoms, or depression/anxiety scores.