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Sănătate mintală și neurodezvoltare

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StudiuScleroză multiplăÎncredere bună22.06.2026

Multiple Sclerosis in Morocco: Epidemiological, Clinical, and Therapeutic Profile

A descriptive study of 170 MS patients across Morocco found female predominance, relapsing-remitting MS as the most common type, and common symptoms including fatigue, cognitive issues, and spasticity. Disease-modifying therapies (interferon beta-1a, azathioprine) were used alongside traditional/complementary medicine (cupping, Quranic recitation, apitherapy), with professional activity, treatment satisfaction, and stress significantly associated with relapse frequency.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Neuroimaging Advances for Monitoring Multiple Sclerosis Worsening: GMSI-Supported Innovations

This review examines recent neuroimaging technologies including MRI, PET, ocular imaging, and machine learning supported by MS research initiatives to better detect early MS pathology and monitor treatment response. The authors emphasize that while these biomarkers show promise for predicting and monitoring disease progression and may serve as clinical trial endpoints, longitudinal studies are needed to translate these measures into routine clinical practice.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Biological aging in multiple sclerosis: mechanisms and therapeutic implications

This review examines how biological aging accelerates disease progression in multiple sclerosis, particularly in progressive forms resistant to current treatments. Evidence from animal models and clinical biomarkers (telomere length, DNA methylation) suggests MS patients experience accelerated aging, opening potential avenues for senotherapy-based interventions targeting aging-related pathways.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Reduced resting beat-to-beat blood pressure variability in females with relapsing-remitting multiple sclerosis

This study examined cardiovascular autonomic dysfunction in women with relapsing-remitting MS by measuring beat-to-beat blood pressure variability and sympathetic baroreflex sensitivity compared to healthy controls. The research hypothesized that reduced sympathetic control in MS patients leads to impaired blood pressure regulation, using continuous electrocardiogram and blood pressure monitoring along with muscle sympathetic nerve activity recordings.

StudiuScleroză multiplăÎncredere bună22.06.2026

The dual role of autophagy in multiple sclerosis: Protective and harmful mechanisms

This review examines autophagy—a cellular degradation process—as a double-edged sword in multiple sclerosis, showing both protective effects (reducing oxidative stress and inflammation) and harmful effects (promoting demyelination when over-activated). The paper discusses how autophagy modulates immune cell activation and oligodendrocyte function, suggesting selective autophagy modulation could be a therapeutic strategy depending on disease context.