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Sănătate mintală și neurodezvoltare

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StudiuDemențeÎncredere înaltă23.06.2026

Unawareness of Deficits in Mild Cognitive Impairment: A Systematic Review of Its Role in Progression to Alzheimer's Disease

This systematic review examines whether reduced awareness of cognitive decline in individuals with mild cognitive impairment (MCI) serves as a predictor of conversion to Alzheimer's disease or dementia. The study synthesized evidence from 11 peer-reviewed longitudinal studies across major databases to clarify whether diminished insight into cognitive abilities in early stages could identify at-risk individuals who need timely intervention.

StudiuDemențeÎncredere bună23.06.2026

Sex Differences in Adverse Childhood Experiences and Brain Structure/Cognition Along the Alzheimer's Disease Continuum

This study investigates why women develop Alzheimer's disease at higher rates by examining how adverse childhood experiences (ACEs) affect brain structure and cognitive function differently in men versus women across stages of cognitive decline. Results show women reported more ACEs, and these experiences were associated with reduced brain volumes in cognitively unimpaired men and memory/executive function deficits in women with mild cognitive impairment, suggesting psychosocial factors may contribute to sex differences in dementia risk.

StudiuDemențeÎncredere înaltă23.06.2026

Digital Speech-Based Markers to Advance Prognosis in Alzheimer's Disease

Speech-based digital markers offer a scalable, non-invasive approach to predicting cognitive decline and complementing blood biomarkers in Alzheimer's disease, though large multilingual longitudinal datasets are lacking. The SpeechDx study is a 3-year multinational observational research program (n=2006) designed to develop and validate speech-based tools for early risk assessment and personalized intervention in preclinical populations.

StudiuDemențeÎncredere bună22.06.2026

Diagnosis of Alzheimer's Dementia and Vehicle Driving Restriction: A Scoping Review

This scoping review examined literature (2000-2022) on driving safety and restrictions for patients with Alzheimer's disease and cognitive decline, finding no sufficiently sensitive psychometric tests to reliably assess driving competence in older adults with cognitive deficits. The authors conclude there is insufficient robust evidence to recommend either continuation or cessation of driving for patients with mild cognitive impairment or mild dementia, while noting driving restrictions can significantly impact patients and families, and that legal regulations on this issue are sparse globally

StudiuDemențeÎncredere înaltă22.06.2026

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

This review examines how tau protein misfolding and accumulation impair blood-brain barrier integrity and vascular function in Alzheimer's disease and other tauopathies, while also exploring how cerebrovascular dysfunction promotes tau pathology. The authors highlight epigenetic and epitranscriptomic mechanisms regulating cerebrovascular integrity and tauopathy progression, with implications for therapeutic intervention.