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This multicenter study externally validated the UPFRONT-model, which predicts functional outcome after mild traumatic brain injury using factors like educational level, consciousness level, neck pain, and psychological variables. The model demonstrated acceptable discrimination ability but systematically underestimated recovery rates (predicted 46% vs observed 75%), suggesting need for calibration adjustments while confirming psychological variables as robust predictors.

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Correlation Between Accommodative Facility and Light-Evoked Pupil Responses in Individuals with Mild Traumatic Brain Injury

This study examined the relationship between pupil light response dynamics and accommodation deficits in 17 individuals with prior mild TBI using objective measurements. Participants with accommodative dysfunction showed significantly larger pupil constriction amplitudes and faster constriction velocity, suggesting a neurophysiological link between these two oculomotor functions post-TBI.

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Ketogenic Interventions for Post-Traumatic Brain Injury Recovery: A Scoping Review of Evidence and Clinical Feasibility

This scoping review systematically examined 32 studies (25 animal, 7 human) on ketogenic therapies for traumatic brain injury, synthesizing mechanistic insights and clinical outcomes. The analysis identifies sex imbalances in TBI research and evaluates barriers to clinical implementation of ketogenic interventions as a potential therapeutic strategy.