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StudiuLeziuni medulareÎncredere înaltă28.06.2026

Defining Abnormal Prostate-Specific Antigen Values for Prostate Cancer Screening in Spinal Cord Injury Patients

This study analyzed nearly 35,000 male veterans with spinal cord injury to establish age-adjusted PSA reference ranges for prostate cancer screening, accounting for factors like chronic urinary tract inflammation and hypogonadism that affect PSA levels in this population. The findings provide clinically relevant PSA threshold values specific to SCI patients, which differ from standard reference ranges used in the general population.

StudiuAVC și AITÎncredere bună28.06.2026

Prevalence of Familial Hypercholesterolemia in Stroke and Transient Ischemic Attack Populations: A Systematic Review and Meta-Analysis

This systematic review synthesizes evidence from four studies to estimate the prevalence of familial hypercholesterolemia (FH) in stroke and TIA patients, finding a pooled prevalence of 0.96% overall and 2.89% in large artery atherosclerosis strokes. The authors acknowledge significant heterogeneity between studies and conclude that while evidence suggests FH may be relevant to cerebrovascular disease beyond cardiology, more research is needed for firm quantitative conclusions.

StudiuAdicțiiÎncredere bună28.06.2026

Effects of Theta Burst Stimulation on Craving Severity and Biomarkers in Gambling Disorder Patients

This research investigates theta burst stimulation, a neuromodulation technique, as a potential treatment for gambling disorder by measuring changes in craving intensity and relevant biological markers. The study examines whether this brain stimulation approach can reduce gambling cravings and identify associated neurobiological changes in affected patients.

StudiuAdicțiiÎncredere bună28.06.2026

Personality and impulsivity traits associated with problematic online gaming and poker playing

This study examined how personality dimensions and impulsivity traits relate to problematic internet usage among 1,144 online MMORPG and poker players using validated psychological instruments. Neuroticism, negative urgency, positive urgency, and sensation seeking were significantly associated with higher addiction scores, while extraversion showed a protective effect, with similar patterns observed across both gaming groups.

StudiuAutismÎncredere bună28.06.2026

Brain-Targeted H₂S-Releasing Nanomicelle Shows Promise in Autism Spectrum Disorder Rat Models via Aerobic Glycolysis Enhancement

Researchers developed a mannose-modified nanomicelle (Man-LA) designed to deliver hydrogen sulfide directly to the brain via GLUT1 transporters in astrocytes, and demonstrated in rat autism models that it alleviates behavioral symptoms while promoting aerobic glycolysis and protecting hippocampal neurons. The study identifies dysregulation of astrocytic aerobic glycolysis and H₂S signaling as potentially important in autism pathophysiology, though these findings remain preclinical and require human validation.

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