NeuroPsy InfoHub adună studii și articole verificate editorial despre sănătate mintală și afecțiuni neurologice — pentru pacienți, familii și specialiști.
This review examines how p75 neurotrophin receptor (p75NTR) contributes to epilepsy development through altered neurotransmitter balance and increased pro-BDNF/p75NTR expression in brain cells. The authors synthesize current evidence on the mechanistic pathways linking p75NTR overexpression to epileptogenesis and seizure pathogenesis.
This case analysis examines a driver with longstanding epilepsy who caused a traffic accident during a seizure-induced state of profound consciousness disturbance, addressing how courts determine criminal responsibility in such situations. The authors argue for expanded legal frameworks requiring multidisciplinary medical evaluation and therapeutic rather than purely penal measures to prevent future incidents and minimize psychiatric complications.
This meta-analysis of 25 observational studies (24,596 pregnancies) found that pregnant women with epilepsy who experience seizures have increased risks of caesarean delivery, peripartum depression, preterm birth, and small-for-gestational-age infants compared to those without seizures. The review also examined how socioeconomic factors may influence seizure control during pregnancy.
This mechanistic review examines shared ion channel dysfunctions (particularly KCNQ1, KCNH2, SCN5A variants) that may simultaneously cause seizure susceptibility and cardiac repolarization abnormalities, proposing an integrated 'cardio-cerebral ion channelopathy' framework for understanding SUDEP risk. The authors discuss critical implications for anti-seizure medication safety assessment and precision medicine strategies in patients with overlapping neurological and cardiac vulnerability.
This study examines patterns of brain electrical synchronization during seizures using EEG network analysis with methods that generalize across different patients. The research contributes to understanding the neurophysiological mechanisms underlying seizure propagation and may inform clinical assessment or treatment approaches.