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StudiuScleroză multiplăÎncredere înaltă22.06.2026

Reduced resting beat-to-beat blood pressure variability in females with relapsing-remitting multiple sclerosis

This study examined cardiovascular autonomic dysfunction in women with relapsing-remitting MS by measuring beat-to-beat blood pressure variability and sympathetic baroreflex sensitivity compared to healthy controls. The research hypothesized that reduced sympathetic control in MS patients leads to impaired blood pressure regulation, using continuous electrocardiogram and blood pressure monitoring along with muscle sympathetic nerve activity recordings.

StudiuScleroză multiplăÎncredere bună22.06.2026

The dual role of autophagy in multiple sclerosis: Protective and harmful mechanisms

This review examines autophagy—a cellular degradation process—as a double-edged sword in multiple sclerosis, showing both protective effects (reducing oxidative stress and inflammation) and harmful effects (promoting demyelination when over-activated). The paper discusses how autophagy modulates immune cell activation and oligodendrocyte function, suggesting selective autophagy modulation could be a therapeutic strategy depending on disease context.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Magnetic resonance fingerprinting in multiple sclerosis: T1 and T2 relaxation time analysis in tissue characterization

This cross-sectional study used magnetic resonance fingerprinting (MRF) to measure T1 and T2 relaxation times in brain tissue of healthy controls, relapsing-remitting MS patients, and secondary progressive MS patients, finding progressive increases in relaxation times across disease stages. The findings suggest MRF may be useful for quantitative tissue characterization and differentiation between MS disease subtypes and disease progression.

StudiuScleroză multiplăÎncredere bună22.06.2026

Neuropsychological Rehabilitation in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review

This systematic review examines scientific evidence on neuropsychological interventions targeting cognitive impairment in people with relapsing-remitting MS, a common disabling neurological disease in young adults. Analysis of 15 articles meeting rigorous inclusion criteria found that most cognitive rehabilitation programs demonstrated effectiveness, though methodological standardization remains lacking in this field.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Horizontal gene transfer in pathogenic bacteria shapes progressive multiple sclerosis

Research identifies a specific strain of Tyzzerella nexilis enriched in secondary progressive MS that carries numerous mobile genetic elements and lacks defence mechanisms against them. In germ-free mice, colonisation with this strain increases susceptibility to experimental autoimmune encephalomyelitis through TLR5 stimulation by flagella and production of neuroactive reduced sulphur compounds, suggesting horizontal gene transfer may drive MS progression via gut microbiome alterations.