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Sănătate mintală și neurodezvoltare

Afecțiuni neurologice

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StudiuDemențeÎncredere înaltă22.06.2026

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

This review examines how tau protein misfolding and accumulation impair blood-brain barrier integrity and vascular function in Alzheimer's disease and other tauopathies, while also exploring how cerebrovascular dysfunction promotes tau pathology. The authors highlight epigenetic and epitranscriptomic mechanisms regulating cerebrovascular integrity and tauopathy progression, with implications for therapeutic intervention.

StudiuDemențeÎncredere înaltă22.06.2026

Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease

This study examined how cognitive reserve—the brain's ability to maintain function despite Alzheimer's pathology—differs between typical and limbic-predominant subtypes of Alzheimer's disease using neuroimaging data from over 500 participants. Results showed that higher cognitive reserve predicted slower cognitive decline, with typical Alzheimer's subtype showing faster reserve deterioration than the limbic-predominant form, highlighting the importance of subtype-specific analyses in understanding disease progression.

StudiuDemențeÎncredere înaltă22.06.2026

Hypertension and Dementia: Pathophysiology and Potential Utility of Antihypertensives in Reducing Disease Burden

This review examines hypertension as a modifiable risk factor for dementia, finding that mid-life hypertension (ages 45-64) correlates with increased cognitive decline and dementia risk, while late-life hypertension shows less consistent associations. Evidence on whether antihypertensive treatment effectively prevents dementia remains conflicting across studies, likely due to methodological differences between observational and randomized controlled trials.

StudiuDemențeÎncredere bună21.06.2026

The Mediterranean Diet as a Potential Defense Against Alzheimer's Disease: A Comprehensive Review

Recent observational studies suggest the Mediterranean diet may be associated with reduced cognitive decline and lower Alzheimer's disease risk, possibly through vascular, metabolic, and anti-inflammatory mechanisms. However, causality has not been established, and large-scale randomized controlled trials are needed to confirm whether the diet can serve as a preventive strategy for dementia.

StudiuDemențeÎncredere bună21.06.2026

Hypertension and Cognitive Disorders: A Review of Associations and Therapeutic Implications

This review examines how hypertension contributes to major neurocognitive disorders including Alzheimer's disease, vascular dementia, and Lewy body dementia through vascular damage, inflammation, and blood-brain barrier disruption. While antihypertensive medications show promise in some studies, evidence remains inconsistent, highlighting the need for long-term prospective research to clarify treatment effectiveness and the bidirectional relationship between hypertension and cognitive decline.