Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity
This review examines how tau protein misfolding and accumulation impair blood-brain barrier integrity and vascular function in Alzheimer's disease and other tauopathies, while also exploring how cerebrovascular dysfunction promotes tau pathology. The authors highlight epigenetic and epitranscriptomic mechanisms regulating cerebrovascular integrity and tauopathy progression, with implications for therapeutic intervention.