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Formal and Informal Care Costs Following Traumatic Brain Injury and Spinal Cord Injury from Motor Vehicle Accidents: A Cross-Sectional Australian Study

This study compared the weekly utilization and associated costs of formal and informal care in 81 people with traumatic brain injury and 30 with spinal cord injury from motor vehicle accidents in Australia. Spinal cord injury (tetraplegia/paraplegia) required significantly higher costs for both formal and informal care, while informal care costs exceeded formal care costs for both conditions, highlighting the critical yet underacknowledged role of family caregiving in supporting recovery.

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Attention and Behavioral Problems as Mediators of Internet Gaming Disorder in Youth With Family Addiction History

This study of 2,586 adolescents (ages 11-19) examined how attention problems and externalizing behaviors mediate the relationship between parental addiction history and internet gaming disorder. Higher attention and externalizing problems were significantly associated with IGD, with mediation analysis confirming these symptoms partially explain how family addiction history increases gaming disorder risk in youth.

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Problematic Social Networking Site Use: Effects on Mental Health and Brain Function

Excessive social networking site use is associated with elevated rates of depression, anxiety, OCD, ADHD, and sleep disturbances, with preliminary neuroimaging evidence suggesting reduced gray matter in regions related to reward processing and inhibitory control. Cognitive Behavior Therapy shows promise as a short-term intervention, though more research is needed to fully understand the neurobiological mechanisms and treatment efficacy.

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Mood instability and mental health service use in autism and ADHD: A natural language processing analysis of 21,906 children and adolescents

This study used natural language processing to analyze electronic health records from over 21,000 children with autism and/or ADHD, examining how baseline mood instability relates to mental health service use patterns. Mood instability was associated with significantly increased annual mental health service use across all diagnostic groups, with the strongest effects in ADHD alone, and reduced time to discharge specifically in the ADHD group.

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Male-Biased Social Deficits in Chd8+/R2219* Mouse Model of Autism Linked to Hippocampal Abnormalities

This preclinical study generated a CRISPR-Cas9 mouse model carrying a CHD8 mutation associated with autism risk and found that male mice exhibited greater social deficits mirroring human sex bias, alongside macrocephaly and whole-brain enlargement. MRI and functional connectivity analyses revealed that hippocampal expansion and disrupted hippocampal network connectivity specifically correlated with social deficit severity in males, establishing hippocampal pathology as a key neural substrate for sex-biased autism phenotypes.