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StudiuEpilepsieÎncredere bună20.06.2026

Pharmacogenetics of Anti-Seizure Medications in Arab Countries: A Comprehensive Review

This review examines how genetic variations in Arab populations influence the efficacy, safety, and individual responses to anti-seizure medications, identifying specific genetic markers that can predict drug resistance and optimize dosing. Genetic testing for variants in genes such as MTHFR, MDR1, ABCB1, and others enables personalized treatment approaches to improve seizure control and minimize adverse drug reactions.

StudiuEpilepsieÎncredere înaltă20.06.2026

ILAE 2025 Classification of Epileptic Seizures: Key Revisions and Clinical Implications

The International League Against Epilepsy released an updated seizure classification in 2025 with six main revisions to improve clinical clarity, including replacing 'onset' in seizure class names, substituting 'consciousness' for 'awareness' to encompass both awareness and responsiveness, and replacing 'motor' with 'observable' features. The update also emphasizes chronological seizure semiology patterns, recognizes epileptic negative myoclonus as a new seizure type, and expands the use of epileptic spasms as a descriptor across focal and unknown seizures.

StudiuEpilepsieÎncredere înaltă20.06.2026

Managing Psychiatric Comorbidities in Epilepsy: A Neurologist's Clinical Guide

Psychiatric disorders commonly coexist with epilepsy but remain underdiagnosed and undertreated due to insufficient mental health resources and neurologist training gaps. This clinical resource provides neurologists with evidence-based strategies to identify and pharmacologically manage reactive symptoms, interictal psychiatric disorders, periictal episodes, and iatrogenic psychiatric effects in their epilepsy patients.