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This prospective study of 271 stroke patients examined the relationship between telomere length (a cellular aging marker) and neurological disability measured by standardized clinical scales (NIHSS and mRS). Shorter telomeres were associated with higher stroke severity scores in ischemic stroke patients, both at emergency department admission and one day later.
This review examines the use of electromagnetic field therapies (including transcranial magnetic stimulation, transcranial direct current stimulation, and pulsed electromagnetic fields) as adjunctive rehabilitation approaches for stroke patients beyond conventional thrombolytic and thrombectomy interventions. The paper discusses the physical principles, molecular mechanisms, and evidence from preclinical and clinical studies supporting EMF applications in functional recovery and stroke monitoring.
A meta-analysis of six randomized controlled trials involving nearly 15,000 patients found that low-dose colchicine (0.5 mg daily) reduced stroke risk by 28% relative to placebo, with stronger effects in patients with established cardiovascular disease. The treatment also showed comparable reductions in major adverse cardiovascular events and received FDA approval in June 2023 for primary cardiovascular prevention.
This comprehensive review examines stem cell therapies for stroke patients, including autologous bone marrow-derived cells administered via intravenous, intrathecal, or intracerebral routes at various post-stroke phases. Early-phase trials demonstrate safety and tolerability with some improvements in NIH Stroke Scale scores, though definitive clinical effectiveness remains unproven and additional research is needed.
This meta-analysis of 45 audits covering 1.18 million stroke patients found that 81.1% received antithrombotic therapy within 48 hours, falling below the 85% quality benchmark established by stroke care guidelines. Treatment delivery rates were comparable between high-income and low-to-middle-income countries, with improvements noted in studies published after 2008.