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StudiuEpilepsieÎncredere bună21.06.2026

Switching from carbamazepine to lacosamide improves elevated gamma-glutamyl transpeptidase levels in focal epilepsy patients

A clinical study of 12 adult epilepsy patients with elevated liver enzyme (GGT) levels found that switching from carbamazepine to lacosamide resulted in significant reduction in GGT levels and normalization in most patients. The medication switch was conducted abruptly without gradual cross-titration and did not result in increased seizure incidence over one month of follow-up.

StudiuEpilepsieÎncredere înaltă21.06.2026

Case Report: Lacosamide Unmasking SCN5A-Associated Brugada Syndrome in a Young Female with Epilepsy

A 33-year-old woman with epilepsy experienced cardiac arrest during intravenous lacosamide treatment, revealing previously undiagnosed Brugada syndrome caused by an SCN5A gene mutation (c.2893C>T, p.Arg965Cys). The case demonstrates a rare but serious adverse interaction between the antiepileptic drug lacosamide and genetic cardiac ion channel susceptibility, highlighting the need for cardiac screening in patients with family history of sudden cardiac death before lacosamide initiation.

StudiuEpilepsieÎncredere bună21.06.2026

Relationship between Anaplastic Lymphoma Kinase Inhibitors and Seizure Disorders: A Post-Marketing Surveillance Study

This pharmacovigilance study analyzed FDA adverse event reports to investigate whether ALK inhibitors (crizotinib, ceritinib, alectinib, brigatinib, lorlatinib) are associated with seizures using Bayesian statistical methods. Results showed varying signal detection scores across different ALK inhibitors, with ceritinib, brigatinib, alectinib, and lorlatinib demonstrating stronger associations with seizure disorders compared to crizotinib.

StudiuEpilepsieÎncredere bună21.06.2026

Optimal EEG Duration for Detecting Epileptiform Abnormalities Across Patient Groups: A Retrospective Analysis

This retrospective study analyzed EEG recordings to determine optimal recording duration for detecting epileptiform abnormalities in patients with first seizure versus established epilepsy. Results showed detection rates of 37.6% and 57.4% respectively, with factors like anti-seizure medication use and seizure frequency significantly influencing detection, suggesting individualized EEG protocols based on clinical presentation.