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StudiuDepresieÎncredere bună27.06.2026

Active versus Sham Transcranial Pulsed Electromagnetic Field Treatment for Major Depression: Protocol for a Double-Blinded Randomised Trial

This protocol describes a double-blinded, sham-controlled randomised trial evaluating transcranial pulsed electromagnetic field (T-PEMF) treatment delivered via a MoodHeadBand for patients with moderate to severe depression who have not responded to conventional therapies. The 8-week study measures depressive symptoms, cognitive function, and sleep quality using validated clinical instruments in 96 participants.

StudiuDepresieÎncredere bună26.06.2026

Patient perspectives on challenges and opportunities in discussing and managing anhedonia in major depressive disorder: a focus group study

This qualitative study explores patient experiences and perspectives on anhedonia (loss of pleasure) as a symptom of major depressive disorder, examining barriers to discussion and management strategies. The research identifies patient-identified challenges and opportunities for improving clinical communication and treatment approaches for this core depressive symptom.

StudiuDepresieÎncredere înaltă26.06.2026

Effects of Antidepressants on Insulin Resistance in Major Depressive Disorder: A Systematic Review

This systematic review evaluates how different antidepressant classes affect insulin resistance, a metabolic complication common in depression. Tricyclic antidepressants (nortriptyline, amitriptyline, imipramine) worsen insulin sensitivity, while SSRIs and SNRIs appear metabolically neutral; bupropion and agomelatine show potential metabolic benefits in diabetic patients.

StudiuDepresieÎncredere înaltă26.06.2026

Three-arm randomised controlled trial of text message reminders and financial incentives to improve antidepressant adherence in primary care depression

This study protocol describes a randomised controlled trial comparing two adherence support strategies (daily text messages with and without financial incentives) against usual care for adults newly prescribed antidepressants in primary care settings. Primary outcomes measure depression symptom response at 12 weeks using the PHQ-9 scale, with secondary outcomes assessing adherence rates at 6 and 12 weeks via wireless pill monitoring.

StudiuDepresieÎncredere bună26.06.2026

Feasibility of diagnosing major depressive disorder with a panel of serum and urine biomarkers

This study tested a machine learning model combining 34 serum and urine biomarkers to objectively diagnose major depressive disorder in 160 patients and 120 controls. The biomarker diagnostic model achieved good internal discrimination (AUC 0.81) but showed moderate performance in internal-external validation (AUC 0.62-0.72), suggesting potential clinical utility pending further validation.

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