Informație de încredere. Sprijin real.

Ai întrebări despre autism, ADHD, anxietate sau depresie? Găsești ghiduri clare, verificate de specialiști. Acum, acces gratuit.

Spațiu publicitar disponibil — bannerul mare de susSpațiu publicitar disponibil — bannerul mare de sus

Explorează temele

Caută tot →

Sănătate mintală și neurodezvoltare

Afecțiuni neurologice

Articole și ghiduri recomandate

StudiuDemențeÎncredere înaltă23.06.2026

Unawareness of Deficits in Mild Cognitive Impairment: A Systematic Review of Its Role in Progression to Alzheimer's Disease

This systematic review examines whether reduced awareness of cognitive decline in individuals with mild cognitive impairment (MCI) serves as a predictor of conversion to Alzheimer's disease or dementia. The study synthesized evidence from 11 peer-reviewed longitudinal studies across major databases to clarify whether diminished insight into cognitive abilities in early stages could identify at-risk individuals who need timely intervention.

StudiuDemențeÎncredere înaltă23.06.2026

Digital Speech-Based Markers to Advance Prognosis in Alzheimer's Disease

Speech-based digital markers offer a scalable, non-invasive approach to predicting cognitive decline and complementing blood biomarkers in Alzheimer's disease, though large multilingual longitudinal datasets are lacking. The SpeechDx study is a 3-year multinational observational research program (n=2006) designed to develop and validate speech-based tools for early risk assessment and personalized intervention in preclinical populations.

StudiuDemențeÎncredere înaltă22.06.2026

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

This review examines how tau protein misfolding and accumulation impair blood-brain barrier integrity and vascular function in Alzheimer's disease and other tauopathies, while also exploring how cerebrovascular dysfunction promotes tau pathology. The authors highlight epigenetic and epitranscriptomic mechanisms regulating cerebrovascular integrity and tauopathy progression, with implications for therapeutic intervention.

StudiuDemențeÎncredere înaltă22.06.2026

Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease

This study examined how cognitive reserve—the brain's ability to maintain function despite Alzheimer's pathology—differs between typical and limbic-predominant subtypes of Alzheimer's disease using neuroimaging data from over 500 participants. Results showed that higher cognitive reserve predicted slower cognitive decline, with typical Alzheimer's subtype showing faster reserve deterioration than the limbic-predominant form, highlighting the importance of subtype-specific analyses in understanding disease progression.

StudiuDemențeÎncredere înaltă22.06.2026

Hypertension and Dementia: Pathophysiology and Potential Utility of Antihypertensives in Reducing Disease Burden

This review examines hypertension as a modifiable risk factor for dementia, finding that mid-life hypertension (ages 45-64) correlates with increased cognitive decline and dementia risk, while late-life hypertension shows less consistent associations. Evidence on whether antihypertensive treatment effectively prevents dementia remains conflicting across studies, likely due to methodological differences between observational and randomized controlled trials.