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Sănătate mintală și neurodezvoltare

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StudiuParkinsonÎncredere înaltă27.06.2026

Correlation between daily physical activity and motor/non-motor symptoms in Parkinson's disease using wearable technology

This cross-sectional study of 80 Parkinson's patients examined relationships between objectively measured daily physical activity (step count) and symptom severity using wearable devices over 6 weeks. Higher daily activity was associated with significantly reduced bradykinesia and paradoxically increased mild dyskinesia, supporting the role of physical activity in managing Parkinson's motor symptoms.

StudiuParkinsonÎncredere înaltă27.06.2026

Parkinson's Disease in Times of War: Gaps in Knowledge and Emerging Controversies

This review examines how wartime conditions—including traumatic brain injury, chronic stress, toxin exposure, and healthcare disruption—influence Parkinson's disease risk and management outcomes. The paper identifies critical gaps in knowledge regarding PD progression in conflict-affected populations and calls for evidence-based humanitarian protocols and telemedicine approaches for neurological care during conflict.

StudiuParkinsonÎncredere înaltă27.06.2026

Characterization of REM Sleep Behavior Disorder Patients with Negative Cerebrospinal Fluid α-Synuclein

This study examined 191 patients with isolated REM sleep behavior disorder (IRBD, a prodromal phase of Parkinson's disease and related conditions) and found that 24.6% tested negative for misfolded α-synuclein in cerebrospinal fluid. Over 5 years of follow-up, α-synuclein-negative patients had significantly lower rates of progression to Parkinson's disease or dementia with Lewy bodies (10.6% vs 42.4%), suggesting they either represent a very early disease stage or have a non-synucleinopathy condition such as antidepressant-related side effects.

StudiuParkinsonÎncredere înaltă27.06.2026

Depression in Persons with Parkinson's Disease: Clinical Perspectives and Management

Depression affects over one-third of Parkinson's disease patients with significant diagnostic challenges due to symptom overlap between the conditions. Treatment involves pharmacotherapy (SSRIs, SNRIs, tricyclics) and psychotherapy (CBT, interpersonal therapy) adapted for PD-specific vulnerabilities, though access to specialized mental health care remains limited.

StudiuParkinsonÎncredere bună27.06.2026

Multi-session neurofeedback with implanted deep brain stimulation electrodes in Parkinson's disease patients

This exploratory study investigated the feasibility of repeated neurofeedback sessions using implanted DBS systems in 8 Parkinson's disease patients, where real-time visual feedback of beta oscillations from the subthalamic nucleus allowed patients to attempt regulation of neural activity across three separate days. Results showed significant beta power reduction in sessions 1 and 3, with dopaminergic medication negatively impacting downregulation performance while DBS stimulation enhanced it.