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Research presented at the European Academy of Neurology Congress 2026 demonstrates that MS substantially affects non-physical aspects of life, with over half of patients reporting impacts on social functioning and nearly half reporting work-related consequences. The study highlights the importance of addressing psychosocial dimensions alongside physical symptoms in MS management.
This cross-sectional study of 222 RRMS patients examined how perfectionism and intolerance of uncertainty contribute to fear of relapse using validated psychological scales. Results showed perfectionism significantly predicts fear of relapse both directly and indirectly through intolerance of uncertainty, which mediates approximately 48% of this relationship.
This study examined urodynamic voiding patterns in 97 MS patients with lower urinary tract symptoms, identifying sphincter dysfunction in 70% and detrusor underactivity in 23%. The research compared performance of six different diagnostic indices for assessing bladder contractility and obstruction, finding variable agreement between these parameters in this MS cohort.
A metabolomic study compared fecal metabolite profiles from 37 MS patients and 30 healthy controls using advanced mass spectrometry and multivariate statistical analysis to identify differential metabolites and their associated metabolic pathways. The research aims to reveal metabolic abnormalities associated with MS and provide insights into disease pathogenesis and potential therapeutic targets.
BTK (Bruton's tyrosine kinase) inhibitors represent a promising therapeutic approach in MS by targeting B-cell activation and immune dysregulation. This review examines the immunobiological mechanisms underlying BTK inhibition and its translation into clinical treatment strategies for multiple sclerosis patients.
