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A case of a middle-aged woman with well-controlled epilepsy who presented with persistent anxiety, depression, and irritability despite adequate psychiatric medication (escitalopram, olanzapine). Investigation revealed temporal lobe epilepsy auras as the underlying cause, and adjustment of anti-seizure therapy with lacosamide resulted in complete symptom resolution and significant functional improvement.
This prospective study of 476 traumatic spinal cord injury patients found that 47% also had concomitant traumatic brain injury, with 85% being mild cases. Risk factors for co-occurring injuries included history of substance abuse, motor vehicle accidents, high-energy mechanisms, and tetraplegia rather than paraplegia.
This umbrella systematic review synthesized 20 systematic reviews to assess the prevalence and correlates of mental illness in traumatic spinal cord injury patients, finding depression (up to 43%), PTSD (up to 62%), anxiety (27%), and hazardous alcohol use (≥50%) as major concerns. Common risk factors included pain, injury severity, low social support, and maladaptive coping, though evidence for effective interventions was limited.
This research focuses on developing language and speech-based biomarkers for early detection of neurocognitive and affective disorders using automated analysis. The LANGaware project aims to improve diagnostic accuracy and early intervention through objective linguistic and acoustic markers.
This integrative review examines CCR5's role as a regulator of neuroinflammation and cognitive function across multiple neurodegenerative and acquired neurological conditions including Alzheimer's disease, Parkinson's disease, MS, TBI, and stroke. Both genetic and pharmacologic CCR5 inhibition show potential to reduce neuroinflammation and preserve cognitive function, though some evidence suggests context-dependent protective roles in certain conditions, highlighting therapeutic complexity.