NeuroPsy InfoHub adună studii și articole verificate editorial despre sănătate mintală și afecțiuni neurologice — pentru pacienți, familii și specialiști.
A study of 287 MS brain tissue samples from the Netherlands Brain Bank identifies specific pathological features, including broad rim lesions and myelin repair failures, that explain variability in disease progression. Individual genetic backgrounds modulate these pathological processes, offering insights into why MS progresses differently among patients.
Researchers identified distinct biological patterns in MS patients' brains that correlate with disease progression rates and severity. These patterns have a genetic component, potentially explaining why some individuals experience rapid disease advancement while others remain stable over extended periods.
This study investigates circulating proteins and microRNAs in cerebrospinal fluid and serum as potential biomarkers to differentiate MS disease subtypes and guide treatment decisions. Analysis of two cohorts identified 13 cerebrospinal fluid proteins and 10 serum proteins that differed between MS patients and controls, with 16 serum microRNAs distinguishing between relapsing-remitting and secondary progressive MS.
This systematic scoping review identified 11 studies examining frailty in people with multiple sclerosis, finding frailty prevalence ranges from 17–66% with early onset compared to the general population. Higher disability levels, longer disease duration, and progressive MS subtypes were consistently associated with frailty, which also correlated with reduced walking performance, poor sleep quality, fatigue, and lower quality of life.
This cross-sectional study of 222 RRMS patients examined how perfectionism and intolerance of uncertainty contribute to fear of relapse using validated psychological scales. Results showed perfectionism significantly predicts fear of relapse both directly and indirectly through intolerance of uncertainty, which mediates approximately 48% of this relationship.
