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StudiuAVC și AITÎncredere înaltă21.06.2026

Efficacy of Low-Dose Colchicine for Stroke Prevention: Meta-Analysis of Randomized Controlled Trials

A meta-analysis of six randomized controlled trials involving nearly 15,000 patients found that low-dose colchicine (0.5 mg daily) reduced stroke risk by 28% relative to placebo, with stronger effects in patients with established cardiovascular disease. The treatment also showed comparable reductions in major adverse cardiovascular events and received FDA approval in June 2023 for primary cardiovascular prevention.

StudiuAVC și AITÎncredere bună21.06.2026

Clinical state and future directions of stem cell therapy in stroke rehabilitation

This comprehensive review examines stem cell therapies for stroke patients, including autologous bone marrow-derived cells administered via intravenous, intrathecal, or intracerebral routes at various post-stroke phases. Early-phase trials demonstrate safety and tolerability with some improvements in NIH Stroke Scale scores, though definitive clinical effectiveness remains unproven and additional research is needed.

StudiuAVC și AITÎncredere înaltă21.06.2026

Systematic Review and Meta-Analysis of Antithrombotic Therapy Delivery Within 48 Hours of Ischemic Stroke

This meta-analysis of 45 audits covering 1.18 million stroke patients found that 81.1% received antithrombotic therapy within 48 hours, falling below the 85% quality benchmark established by stroke care guidelines. Treatment delivery rates were comparable between high-income and low-to-middle-income countries, with improvements noted in studies published after 2008.

StudiuAVC și AITÎncredere înaltă21.06.2026

Comparison of American and European Guideline Recommendations for Diagnostic Workup and Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack

This study compares stroke diagnostic and secondary prevention recommendations between American Heart Association/American Stroke Association (AHA/ASA) and European Stroke Organization (ESO) guidelines, analyzing 63 ESO and 82 AHA/ASA recommendations across 7 key topics. While most recommendations are similar, the guidelines assign different levels of evidence quality to many recommendations, with notable discrepancies in high-level evidence classifications.

StudiuAVC și AITÎncredere bună21.06.2026

Non-alcoholic fatty liver disease as a predictor of recurrent ischemic stroke and transient ischemic attack in carotid atherosclerosis

This retrospective study of 742 patients with carotid atherosclerosis found that non-alcoholic fatty liver disease (NAFLD) is independently associated with increased risk of recurrent ischemic stroke or transient ischemic attack during follow-up. A combined predictive model incorporating NAFLD status, clinical variables, and carotid plaque characteristics demonstrated superior performance in identifying high-risk patients for secondary stroke events.