Case Report: Lacosamide Unmasking SCN5A-Associated Brugada Syndrome in a Young Female with Epilepsy
A 33-year-old woman with epilepsy experienced cardiac arrest during intravenous lacosamide treatment, revealing previously undiagnosed Brugada syndrome caused by an SCN5A gene mutation (c.2893C>T, p.Arg965Cys). The case demonstrates a rare but serious adverse interaction between the antiepileptic drug lacosamide and genetic cardiac ion channel susceptibility, highlighting the need for cardiac screening in patients with family history of sudden cardiac death before lacosamide initiation.