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StudiuScleroză multiplăÎncredere bună22.06.2026

The dual role of autophagy in multiple sclerosis: Protective and harmful mechanisms

This review examines autophagy—a cellular degradation process—as a double-edged sword in multiple sclerosis, showing both protective effects (reducing oxidative stress and inflammation) and harmful effects (promoting demyelination when over-activated). The paper discusses how autophagy modulates immune cell activation and oligodendrocyte function, suggesting selective autophagy modulation could be a therapeutic strategy depending on disease context.

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Magnetic resonance fingerprinting in multiple sclerosis: T1 and T2 relaxation time analysis in tissue characterization

This cross-sectional study used magnetic resonance fingerprinting (MRF) to measure T1 and T2 relaxation times in brain tissue of healthy controls, relapsing-remitting MS patients, and secondary progressive MS patients, finding progressive increases in relaxation times across disease stages. The findings suggest MRF may be useful for quantitative tissue characterization and differentiation between MS disease subtypes and disease progression.

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Neuropsychological Rehabilitation in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review

This systematic review examines scientific evidence on neuropsychological interventions targeting cognitive impairment in people with relapsing-remitting MS, a common disabling neurological disease in young adults. Analysis of 15 articles meeting rigorous inclusion criteria found that most cognitive rehabilitation programs demonstrated effectiveness, though methodological standardization remains lacking in this field.

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Horizontal gene transfer in pathogenic bacteria shapes progressive multiple sclerosis

Research identifies a specific strain of Tyzzerella nexilis enriched in secondary progressive MS that carries numerous mobile genetic elements and lacks defence mechanisms against them. In germ-free mice, colonisation with this strain increases susceptibility to experimental autoimmune encephalomyelitis through TLR5 stimulation by flagella and production of neuroactive reduced sulphur compounds, suggesting horizontal gene transfer may drive MS progression via gut microbiome alterations.

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Executive Functions in Relapsing-Remitting Multiple Sclerosis: A Comparative Study of Working Memory and Cognitive Control

This study compared executive function performance in 24 individuals with relapsing-remitting multiple sclerosis and 24 matched healthy controls using standardized cognitive tests. Results showed selective impairment in divided attention and working memory updating in MS patients under high cognitive demand, while attentional shifting and inhibition remained intact.