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Sănătate mintală și neurodezvoltare

Afecțiuni neurologice

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StudiuScleroză multiplăÎncredere înaltă22.06.2026

Neuroimaging Advances for Monitoring Multiple Sclerosis Worsening: GMSI-Supported Innovations

This review examines recent neuroimaging technologies including MRI, PET, ocular imaging, and machine learning supported by MS research initiatives to better detect early MS pathology and monitor treatment response. The authors emphasize that while these biomarkers show promise for predicting and monitoring disease progression and may serve as clinical trial endpoints, longitudinal studies are needed to translate these measures into routine clinical practice.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Cryptococcal Skin Infection in a Multiple Sclerosis Patient on Fingolimod: A Case Report

A 33-year-old woman with relapsing-remitting MS treated with fingolimod for 5 years developed a solitary skin lesion that proved to be cryptococcal infection on biopsy, likely due to severe lymphocyte suppression from the immunosuppressive therapy. The case highlights the importance of thorough investigation of persistent skin lesions in MS patients on fingolimod, as only 6 such cutaneous cryptococcal infections have been previously reported in the literature.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Alemtuzumab for Multiple Sclerosis: A Cochrane Systematic Review

This Cochrane review evaluates the efficacy and safety of alemtuzumab, a humanized monoclonal antibody, for treating various forms of multiple sclerosis compared to placebo or other active treatments. Primary outcomes include relapse-free survival, sustained disease progression, and adverse events, with secondary measures encompassing disability progression, quality of life, and MRI-detected lesions.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Biological aging in multiple sclerosis: mechanisms and therapeutic implications

This review examines how biological aging accelerates disease progression in multiple sclerosis, particularly in progressive forms resistant to current treatments. Evidence from animal models and clinical biomarkers (telomere length, DNA methylation) suggests MS patients experience accelerated aging, opening potential avenues for senotherapy-based interventions targeting aging-related pathways.

StudiuScleroză multiplăÎncredere înaltă22.06.2026

Reduced resting beat-to-beat blood pressure variability in females with relapsing-remitting multiple sclerosis

This study examined cardiovascular autonomic dysfunction in women with relapsing-remitting MS by measuring beat-to-beat blood pressure variability and sympathetic baroreflex sensitivity compared to healthy controls. The research hypothesized that reduced sympathetic control in MS patients leads to impaired blood pressure regulation, using continuous electrocardiogram and blood pressure monitoring along with muscle sympathetic nerve activity recordings.