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StudiuDepresieÎncredere bună26.06.2026

Animal-Assisted Therapy for Older Adults in Korea: Effects on Depression and Cognitive Function

This review examines animal-assisted therapy (AAT), particularly canine-assisted programs, as a non-pharmacological intervention for depression and cognitive decline in older Korean adults. Evidence shows AAT reduces depression through emotional bonding and social interaction while improving cognitive functions like attention and memory, with effects measured using validated geriatric assessment tools.

StudiuDepresieÎncredere înaltă26.06.2026

Three-arm randomised controlled trial of text message reminders and financial incentives to improve antidepressant adherence in primary care depression

This study protocol describes a randomised controlled trial comparing two adherence support strategies (daily text messages with and without financial incentives) against usual care for adults newly prescribed antidepressants in primary care settings. Primary outcomes measure depression symptom response at 12 weeks using the PHQ-9 scale, with secondary outcomes assessing adherence rates at 6 and 12 weeks via wireless pill monitoring.

StudiuDepresieÎncredere bună26.06.2026

Feasibility of diagnosing major depressive disorder with a panel of serum and urine biomarkers

This study tested a machine learning model combining 34 serum and urine biomarkers to objectively diagnose major depressive disorder in 160 patients and 120 controls. The biomarker diagnostic model achieved good internal discrimination (AUC 0.81) but showed moderate performance in internal-external validation (AUC 0.62-0.72), suggesting potential clinical utility pending further validation.

StudiuDepresieÎncredere bună26.06.2026

Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Major Depressive Disorder

A longitudinal fMRI study tracked 48 patients with major depressive disorder over 8 weeks to identify neural biomarkers of treatment response, finding differential amygdala-supplementary motor area connectivity patterns between those who remitted versus those who did not respond to antidepressants. While baseline connectivity correlated with treatment outcomes and normalized with successful treatment, the findings require replication as they did not survive multiple comparisons correction.

StudiuDepresieÎncredere bună26.06.2026

Association between childhood trauma and 26-week treatment response in adolescents with major depressive disorder: a cohort study

This prospective cohort study of 150 adolescents with major depressive disorder found high prevalence of childhood trauma (emotional abuse 52%, emotional neglect 61.3%), with emotional abuse and neglect significantly associated with poorer treatment response at 26-week follow-up. The findings suggest childhood trauma adversely impacts antidepressant treatment efficacy in adolescents and highlight the need for trauma-informed care in depression management.