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Researchers developed a tablet-based software application designed to slow cognitive and communicative decline in individuals with Alzheimer's disease for home use. A randomized controlled trial with 32 participants (mild, moderate, and severe stages) compared outcomes between those using the application plus pharmacological treatment versus pharmacological treatment alone.
This health economics study examines costs associated with using neuroimaging (PET and MRI) to identify Alzheimer's disease patients most likely to benefit from lecanemab treatment over three years. The authors highlight a critical concern: approximately 78% of patients with mild cognitive impairment do not progress to dementia, making prophylactic treatment in all MCI patients costly and ethically problematic; they identify combined fluorodeoxyglucose and MRI imaging as the most cost-efficient approach at $177,000 per positive outcome with adjusted lecanemab pricing.
This neuroimaging study compared brain structural connectivity in 25 individuals with gambling disorder versus 28 healthy controls using diffusion tensor imaging and probabilistic tractography. The gambling disorder group showed increased striatal connectivity but reduced frontal lobe connectivity and fewer neural hubs, suggesting impaired network integration related to risk-taking control.
This study examined how children with social anxiety disorder (SAD) perceive their social performance compared to objective observer ratings, finding that children with SAD consistently rate themselves more negatively than peers despite similar actual performance. Repeated exposure to social-evaluative tasks with brief parental support or self-instruction improved children's self-ratings over time, though negative self-appraisal remained a core feature of childhood SAD.
This study compared attentional patterns in 42 children with social anxiety disorder (SAD) and 46 healthy controls during anticipation of a social stress task. While reaction time measures showed no group differences, eye-tracking revealed that children with SAD fixated more frequently and longer on audience faces, suggesting heightened hypervigilance to social cues that standard behavioral measures may not capture.