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This transdiagnostic study investigates how autistic traits manifest across patients with mood and psychotic spectrum disorders in an outpatient setting. The research uses empirical methods to map trait profiles, potentially improving diagnostic precision and treatment approaches for individuals with overlapping presentations.
This scoping review examines theatre-based interventions as a therapeutic approach for individuals with autism spectrum disorder across different age groups. The review synthesizes evidence on how theatrical techniques may support social communication, emotional expression, and other developmental outcomes in autistic populations.
This study adapted the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) into Brazilian Portuguese following international guidelines, with validation in 142 autistic adults. The adapted scale demonstrated adequate semantic equivalence and a 14-item screening model showed acceptable fit indices, though psychometric refinements may be needed for clinical use.
Researchers developed a mannose-modified nanomicelle (Man-LA) designed to deliver hydrogen sulfide directly to the brain via GLUT1 transporters in astrocytes, and demonstrated in rat autism models that it alleviates behavioral symptoms while promoting aerobic glycolysis and protecting hippocampal neurons. The study identifies dysregulation of astrocytic aerobic glycolysis and H₂S signaling as potentially important in autism pathophysiology, though these findings remain preclinical and require human validation.
This validation study examined the German version of the Anxiety Scale for Children with Autism Spectrum Disorder-Parent Version (ASC-ASD-P) in 317 youth at an autism clinic, including 120 autistic children, demonstrating excellent internal consistency and convergent validity with established behavioral measures. Autistic youth showed higher anxiety and uncertainty scores than non-autistic peers, confirming the scale's sensitivity to autism-specific anxiety presentations, though some subscales require refinement for broader applicability across the autism spectrum.