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StudiuAutism + ADHDÎncredere bună20.06.2026

CCR5 as a key modulator in neurocognitive disorders: mechanisms and therapeutic implications

This integrative review examines CCR5's role as a regulator of neuroinflammation and cognitive function across multiple neurodegenerative and acquired neurological conditions including Alzheimer's disease, Parkinson's disease, MS, TBI, and stroke. Both genetic and pharmacologic CCR5 inhibition show potential to reduce neuroinflammation and preserve cognitive function, though some evidence suggests context-dependent protective roles in certain conditions, highlighting therapeutic complexity.

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Neural Correlates of Personality Traits in Adolescents with Excessive Smartphone Use: A Resting-State fMRI Study

This study examined brain connectivity patterns in 31 adolescents with excessive smartphone use versus 31 healthy controls using resting-state fMRI, finding altered functional connectivity in the salience network (middle cingulate cortex and insula) associated with lower persistence personality traits. Adolescents with excessive smartphone use showed enhanced connectivity between key brain regions linked to attention and reward processing, correlating with reduced persistence and increased harm avoidance traits.

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Evaluation of NTG-EDSD Dementia Screening Tool in Adults with Down Syndrome

A cohort study of 54 adults with Down syndrome (age ≥40) evaluated the NTG-EDSD screening tool for dementia/mild cognitive impairment, testing various scoring thresholds for sensitivity and specificity. While the tool shows promise for initiating clinical conversations and identifying need for further evaluation, it lacks sufficient standalone diagnostic accuracy for reliable dementia screening in this population.

StudiuAutism + ADHDÎncredere bună20.06.2026

Comorbidity of Autism Spectrum Disorder and Personality Disorders with Eating Disorders, PTSD, and Somatic Symptom Disorder: Clinical Challenges and Treatment Implications

This clinical review examines the prevalence and mechanisms underlying comorbidity between autism spectrum disorder, eating disorders, and PTSD when occurring alongside personality disorders, noting that such combinations typically increase symptom severity and suicide risk. Evidence-based treatments exist but novel approaches are needed, with future research prioritizing ASD-personality disorder trajectories and trauma-informed interventions addressing emotion dysregulation and patient engagement.

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Dynamic limbic-executive decoupling underpins the reciprocal link between drug-resistant epilepsy and depression in temporal lobe epilepsy

This neuroimaging study of 82 temporal lobe epilepsy patients and 50 controls examined whether disrupted functional connectivity between limbic and executive brain networks explains the bidirectional relationship between drug-resistant seizures and depression. Using resting-state fMRI combined with receptor mapping and gene expression analysis, the researchers identified specific patterns of brain network integration that statistically link drug resistance severity and depression symptoms.