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Structure-Function Multilayer Network Integration and Cognition in Multiple Sclerosis

This study examined how integrated structural and functional brain networks in the frontoparietal region relate to cognitive performance in 780 people with relapsing-remitting MS. Higher multilayer network centrality and single-layer network parameters showed weak associations with cognitive test performance, but findings were not reproducible across different brain atlases, limiting their practical significance.

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Effect of Brain Gym on Cognition, Manual Dexterity and Bimanual Coordination in Multiple Sclerosis Patients

This randomized controlled trial compared educational kinesiology (brain gym) combined with conventional physical therapy against conventional therapy alone in 36 MS patients with mild cognitive impairment. The study group receiving brain gym showed significant improvements in cognitive function and hand coordination measures assessed via RehaCom and Purdue Pegboard tests over 4 weeks of treatment.

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Psychological resilience predicts medication adherence in multiple sclerosis

A study of 165 people with relapsing-remitting multiple sclerosis found that psychological resilience independently predicts better medication adherence to disease-modifying therapies, even after accounting for depression, anxiety, stress, quality of life, and disability level. Those with good adherence showed significantly higher resilience scores and lower psychological distress compared to poorly adherent patients.

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Defining Activity-Based Subgroups in Multiple Sclerosis: A Review and Framework Proposal

This systematic review examines how multiple sclerosis is stratified into activity-based subgroups across clinical trials and regulatory guidance, identifying significant inconsistencies in terminology and definitions for 'active', 'highly active', and 'rapidly evolving severe' disease. The authors propose a standardized framework to improve consistency in treatment decision-making and health technology assessments.