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StudiuEpilepsieÎncredere înaltă19.06.2026

Treatment-Resistant Epilepsy with Psychogenic Non-Epileptic Seizures and Intellectual Disability Associated with Balanced t(14;X) Translocation: A Case Report

A woman in her 30s with treatment-resistant epilepsy, psychogenic non-epileptic seizures, intellectual disability, and psychosis caused by a maternally inherited balanced chromosomal translocation continued experiencing daily seizures despite multiple antiepileptic drugs, vagus nerve stimulation, and deep brain stimulation of the anterior thalamic nuclei. The case demonstrates the complex relationship between epilepsy, psychiatric comorbidities, neurostimulation side effects (including forced normalization), and suggests genetic disruption of neurodevelopmental genes regulating inhibitory sign

StudiuEpilepsieÎncredere înaltă19.06.2026

Treatment adequacy outweighs treatment sequence in non-convulsive status epilepticus

This clinical study of 189 adult patients found that inadequate dosing of anti-seizure medications was independently associated with treatment failure and higher mortality in non-convulsive status epilepticus, regardless of treatment sequence. The research suggests that ensuring appropriate medication dosing is more critical than the specific order of drug administration in managing this condition.

StudiuEpilepsieÎncredere înaltă19.06.2026

Epileptic Seizure Detection from EEG Signals Using Long Short-Term Memory-Transformer with Self-Supervised Learning

This study proposes SALT, a deep learning model combining LSTM-Transformer architecture with self-supervised pretraining to detect epileptic seizures from EEG signals without requiring large labeled datasets. The method achieved >98% sensitivity and accuracy on two public benchmark datasets using both segment-based and event-based evaluation protocols.

StudiuEpilepsieÎncredere bună19.06.2026

DIRAS2 modulates MAPK pathway-mediated ferroptosis to regulate excitation/inhibition balance and seizure susceptibility

This study identifies DIRAS2, a Ras-related GTPase, as a regulator of seizure susceptibility through its effects on neuronal excitation/inhibition balance and ferroptosis pathways in epilepsy models and temporal lobe epilepsy patients. DIRAS2 overexpression reduces seizure activity and protects against ferroptosis via inhibition of ERK/p38 MAPK signaling, identifying a potential therapeutic target for epilepsy treatment.

StudiuEpilepsieÎncredere bună19.06.2026

Tracheal Intubation in Children with Uncontrolled Seizures in a Pediatric Emergency Department

A retrospective study of 56 children (ages 0-21) presenting to a pediatric ED with active seizures found that 46% required intubation, most commonly for airway protection or respiratory failure. Intubated patients typically had complex febrile seizures, longer seizure duration, and required multiple antiseizure medications for control.

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Articole și ghiduri recomandate

Treatment-Resistant Epilepsy with Psychogenic Non-Epileptic Seizures and Intellectual Disability Associated with Balanced t(14;X) Translocation: A Case Report

Treatment adequacy outweighs treatment sequence in non-convulsive status epilepticus

Epileptic Seizure Detection from EEG Signals Using Long Short-Term Memory-Transformer with Self-Supervised Learning

DIRAS2 modulates MAPK pathway-mediated ferroptosis to regulate excitation/inhibition balance and seizure susceptibility

Tracheal Intubation in Children with Uncontrolled Seizures in a Pediatric Emergency Department