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StudiuAutism + ADHDÎncredere bună21.06.2026

Long-term changes in behavioral addiction symptoms among adults with ADHD treated with methylphenidate

A one-year prospective study of 37 adults with ADHD found that methylphenidate treatment significantly reduced symptoms of internet, shopping, food, and sex addictions, with the proportion of patients having at least one behavioral addiction diagnosis decreasing from 51.4% to 35.1%. Changes in cognitive impulsivity, sluggish cognitive tempo, and mood/anxiety symptoms correlated moderately with improvements in internet addiction scores.

StudiuAutism + ADHDÎncredere înaltă21.06.2026

Infantile Spasms in Pediatric Down Syndrome: Neurobiological Mechanisms and Therapeutic Approaches

This review examines why infantile spasms commonly occur in Down syndrome by analyzing animal models (Ts65Dn and TcMAC21 mice) to identify abnormalities in brain excitation and inhibition, particularly involving GABA receptor dysfunction. The research provides insights into potential therapeutic targets by clarifying the neurobiological mechanisms underlying seizure predisposition in Down syndrome.

StudiuAutism + ADHDÎncredere înaltă21.06.2026

Effect of Educational Interventions on Psychiatrists' Adherence to Treatment Guidelines for Schizophrenia and Depression: A Multicenter Implementation Study

The EGUIDE project evaluated how educational lectures on clinical practice guidelines influenced 782 psychiatrists' treatment practices across 176 Japanese hospitals, comparing guideline adherence in over 11,000 patients with schizophrenia or major depressive disorder. Psychiatrists who participated in guideline education showed higher rates of guideline-recommended treatments including appropriate antipsychotic monotherapy and reduced unnecessary psychotropic co-prescriptions.

StudiuAutism + ADHDÎncredere bună20.06.2026

Validation of the 10-Item Depression, Anxiety and Stress Scale in Mild Traumatic Brain Injury Patients

This study evaluated the psychometric properties of the DASS-10 in 354 treatment-seeking adults with mild TBI, finding good fit to the Rasch model with high internal consistency and acceptable unidimensionality. Results support the DASS-10 as a reliable, brief screening tool for psychological distress in post-mild TBI outpatient populations.

StudiuAutism + ADHDÎncredere bună20.06.2026

Pathogenesis of Comorbid Epilepsy in Alzheimer's Disease and the Role of Perampanel as an AMPA Receptor Inhibitor

Alzheimer's disease and epilepsy frequently co-occur and share common pathogenic mechanisms involving AMPA-type glutamate receptors. Perampanel, an FDA-approved AMPAR antagonist for seizure management, may offer therapeutic benefits in patients with comorbid AD-epilepsy, particularly those with myoclonus or sleep disturbances, though clinical evidence remains limited.

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