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StudiuAVC și AITÎncredere înaltă20.06.2026

Cerebrovascular Events After Head and Neck Radiation Therapy: Systematic Review and Meta-Analysis

This systematic review and meta-analysis of 50 studies demonstrates that head and neck cancer patients receiving radiation therapy have a significantly increased risk of ischemic stroke (8.98 per 1,000 person-years) and carotid stenosis compared to surgical or non-treated populations. The relative risk of stroke is approximately 1.3 times higher in irradiated patients, with carotid stenosis incidence ranging from 0-40% depending on follow-up duration.

StudiuAVC și AITÎncredere înaltă20.06.2026

Beyond Anticoagulation: Understanding Medical Therapy Failure in PFO-Related Stroke and the Case for Closure

This narrative review examines why anticoagulation fails in some patients with patent foramen ovale (PFO)-related cryptogenic stroke, synthesizing evidence showing transcatheter closure is superior to medical therapy in appropriately selected patients. The analysis incorporates pathophysiological mechanisms, randomized trial comparisons, and risk stratification tools (RoPE score, PASCAL classification) to guide optimal therapeutic selection.

StudiuAVC și AITÎncredere bună20.06.2026

Pre-stroke sleep quality predicts 1-year mortality and functional outcomes in ischemic stroke and TIA patients

This cohort study of 2,266 stroke/TIA patients found that poor pre-stroke subjective sleep quality (highest PSQI quartile) significantly increased 1-year mortality risk (3.73-fold) and poor functional outcome risk (2.15-fold) compared to good sleep quality. The association remained independent after adjusting for confounders, suggesting sleep quality as a prognostic marker in acute ischemic stroke.

StudiuAVC și AITÎncredere bună20.06.2026

Cervicocerebral atherosclerosis and atrial fibrillation increase long-term mortality in ischemic stroke patients

This study of 406 acute ischemic stroke/TIA patients found that atrial fibrillation combined with high cervicocerebral atherosclerotic burden significantly increased 7-year mortality risk, with those having AF and high atherosclerosis burden facing approximately 3-fold greater mortality risk. The findings suggest that concurrent presence of these two vascular conditions substantially worsens long-term outcomes compared to either condition alone.