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An FDA-approved rheumatoid arthritis drug that blocks IL-6 receptors significantly reduced excessive alcohol consumption in alcohol-dependent female mice by suppressing neuroinflammation in the central amygdala. This mechanism aligns with elevated IL-6 expression observed in postmortem brain tissue from individuals with alcohol use disorder, suggesting a potential therapeutic target.
This neuroimaging study compared brain structural connectivity in 25 individuals with gambling disorder versus 28 healthy controls using diffusion tensor imaging and probabilistic tractography. The gambling disorder group showed increased striatal connectivity but reduced frontal lobe connectivity and fewer neural hubs, suggesting impaired network integration related to risk-taking control.
This retrospective cohort study analyzed medication prescribing patterns for 101 adolescents and young adults (mean age 18.5 years) with opioid use disorder and co-occurring psychiatric conditions, finding high rates of polypharmacy (79.2%), medication switching (91.2%), and treatment non-persistence. Depression, anxiety disorders, and ADHD were the most common psychiatric comorbidities, with non-persistence particularly prevalent in depression (63.2%) and bipolar disorder (66.7%).
This study compared reward processing between adolescents with Internet Gaming Disorder (IGD) and recreational game users using established behavioral tasks measuring sensitivity to monetary and social rewards. Adolescents with IGD showed faster reaction times to combined rewards but no differences in response to individual reward types, suggesting reward processing specificity related to stimulus complexity in gaming disorder.
This research investigates theta burst stimulation, a neuromodulation technique, as a potential treatment for gambling disorder by measuring changes in craving intensity and relevant biological markers. The study examines whether this brain stimulation approach can reduce gambling cravings and identify associated neurobiological changes in affected patients.
