Ai întrebări despre autism, ADHD, anxietate sau depresie? Găsești ghiduri clare, verificate de specialiști. Acum, acces gratuit.
A study of 403 epileptic children who discontinued anti-seizure medication after ≥2 years seizure-free identified that 12.7% experienced seizure relapse, with highest rates in genetic (25%) and structural (14.9%) etiologies. Key predictors of relapse included diagnosis age >2 years, defined etiology, focal seizures, and rapid medication withdrawal (<3 months).
This review examines how p75 neurotrophin receptor (p75NTR) contributes to epilepsy development through altered neurotransmitter balance and increased pro-BDNF/p75NTR expression in brain cells. The authors synthesize current evidence on the mechanistic pathways linking p75NTR overexpression to epileptogenesis and seizure pathogenesis.
This case analysis examines a driver with longstanding epilepsy who caused a traffic accident during a seizure-induced state of profound consciousness disturbance, addressing how courts determine criminal responsibility in such situations. The authors argue for expanded legal frameworks requiring multidisciplinary medical evaluation and therapeutic rather than purely penal measures to prevent future incidents and minimize psychiatric complications.
Hemispherotomy is a neurosurgical technique that disconnects one cerebral hemisphere to control severe, drug-resistant seizures in children following traumatic brain injury. This specialized intervention is considered when epilepsy originating from one hemisphere cannot be managed with medications, offering potential seizure control through anatomical brain disconnection rather than tissue removal.
This mechanistic review examines shared ion channel dysfunctions (particularly KCNQ1, KCNH2, SCN5A variants) that may simultaneously cause seizure susceptibility and cardiac repolarization abnormalities, proposing an integrated 'cardio-cerebral ion channelopathy' framework for understanding SUDEP risk. The authors discuss critical implications for anti-seizure medication safety assessment and precision medicine strategies in patients with overlapping neurological and cardiac vulnerability.