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AVC și AIT

Accident vascular cerebral și recuperare, la orice vârstă.

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StudiuAVC și AITÎncredere bună22.06.2026

Association of Thyroid Peroxidase Antibody with RNF213 p.R4810K Variant in Ischemic Stroke and Transient Ischemic Attack

This multicenter study of 2,090 stroke/TIA patients examined whether elevated thyroid peroxidase antibody (TPO-Ab) levels are associated with the RNF213 p.R4810K genetic variant, known to increase vasculopathy risk. Variant carriers showed significantly higher TPO-Ab levels and increased frequency of elevated antibody titers, suggesting TPO-Ab may act as a second hit in RNF213-related stroke pathogenesis.

StudiuAVC și AITÎncredere bună22.06.2026

Reader Response: Association of Alternative Anticoagulation Strategies and Outcomes in Patients With Ischemic Stroke on Direct Oral Anticoagulants

This peer commentary examines clinical outcomes associated with different anticoagulation approaches in patients experiencing ischemic stroke while taking direct oral anticoagulants (DOACs). The response contributes to evidence-based discussion on stroke management strategies in anticoagulated populations.

StudiuAVC și AITÎncredere înaltă22.06.2026

Individualized Interpretation of FLAIR Vessel Hyperintensity in Ischemic Stroke and Transient Ischemic Attack: A Systematic Review

This systematic review examines FLAIR vessel hyperintensity (FVH), an imaging finding reflecting critically slowed blood flow in large artery steno-occlusions, and its clinical significance for predicting prognosis, stroke severity, infarction volume, and functional outcomes in acute ischemic stroke and TIA. The authors address conflicting findings in the literature and propose key factors for individualizing clinical interpretation of this neuroimaging marker to guide clinical decision-making.

StudiuAVC și AITÎncredere înaltă22.06.2026

Cost-Effectiveness of CYP2C19 Genotype-Guided Antiplatelet Therapy for Acute Minor Ischemic Stroke and High-Risk TIA in China

A pharmacoeconomic study evaluated whether personalizing antiplatelet therapy based on CYP2C19 genetic testing (using cilostazol or ticagrelor) is cost-effective compared to standard clopidogrel plus aspirin treatment for minor stroke and high-risk transient ischemic attack in China. The analysis found genotype-guided strategies were cost-effective with incremental cost-effectiveness ratios below accepted thresholds, with robust results across sensitivity analyses.

StudiuAVC și AITÎncredere înaltă22.06.2026

Cardiac complications following cerebrovascular disease: Comparative analysis of stroke types

This study examined cardiac complications in 721 stroke patients across three cerebrovascular event types (ischemic stroke, transient ischemic attack, and hemorrhagic stroke). Results showed ECG changes were most frequent in ischemic stroke (81.7%), with myocardial alterations common across all groups, suggesting important brain-heart interactions following stroke.

StudiuAVC și AITÎncredere bună22.06.2026

Dipping Pattern and 1-Year Stroke Functional Outcome in Ischemic Stroke or Transient Ischemic Attack

This cohort study of 1,808 patients examined whether nocturnal blood pressure dipping patterns predict 1-year functional outcomes after stroke or TIA. While reverse dipping (less than 0% nocturnal systolic BP drop) was associated with worse outcomes in initial analysis, this association became non-significant after adjusting for confounding variables.

StudiuAVC și AITÎncredere bună22.06.2026

Effect of Outpatient Cardiac Rehabilitation on Motor Function and Quality of Life in Stroke Survivors

This randomized controlled study examined whether outpatient cardiac rehabilitation (CR) following in-hospital stroke rehabilitation improves motor function and health-related quality of life in 128 stroke survivors (mean age 73.5 years). Patients receiving 3 months of supervised outpatient CR showed significantly greater improvements in walking distance and leg muscle strength compared to controls, though quality of life measures did not significantly improve.

StudiuAVC și AITÎncredere înaltă21.06.2026

Accelerated Biological Aging as a Predictor of Short- and Long-term Stroke Outcomes in Ischemic Stroke and TIA Patients

This prospective study of 7,396 stroke/TIA patients from China found that accelerated biological age—calculated using three established algorithms (PhenoAge, Klemera-Doubal, HD)—is associated with increased risk of poor stroke outcomes both short- and long-term. Patients with the highest PhenoAge acceleration showed nearly double the risk of adverse events compared to those with the lowest acceleration.

StudiuAVC și AITÎncredere înaltă21.06.2026

Low thrombin inactivation capacity associated with increased recurrent ischemic stroke risk in young adults

This prospective cohort study of 332 young stroke survivors (median 7.6 years post-index event) identified that lower antithrombin levels, higher fibrinogen, and reduced thrombin decay (indicating lower inactivation capacity) were associated with higher recurrent ischemic event risk over 6.5 years of follow-up. The findings suggest that impaired thrombin regulation may contribute to recurrent stroke pathology in younger patients and warrant further investigation as a potential therapeutic target.

StudiuAVC și AITÎncredere bună21.06.2026

Association between Telomere Length and Neurological Disability in Stroke Patients: Analysis by Stroke Type

This prospective study of 271 stroke patients examined the relationship between telomere length (a cellular aging marker) and neurological disability measured by standardized clinical scales (NIHSS and mRS). Shorter telomeres were associated with higher stroke severity scores in ischemic stroke patients, both at emergency department admission and one day later.

StudiuAVC și AITÎncredere bună21.06.2026

Electromagnetic Fields in Ischemic Stroke Rehabilitation and Monitoring: From Laboratory to Clinical Application

This review examines the use of electromagnetic field therapies (including transcranial magnetic stimulation, transcranial direct current stimulation, and pulsed electromagnetic fields) as adjunctive rehabilitation approaches for stroke patients beyond conventional thrombolytic and thrombectomy interventions. The paper discusses the physical principles, molecular mechanisms, and evidence from preclinical and clinical studies supporting EMF applications in functional recovery and stroke monitoring.

StudiuAVC și AITÎncredere înaltă21.06.2026

Efficacy of Low-Dose Colchicine for Stroke Prevention: Meta-Analysis of Randomized Controlled Trials

A meta-analysis of six randomized controlled trials involving nearly 15,000 patients found that low-dose colchicine (0.5 mg daily) reduced stroke risk by 28% relative to placebo, with stronger effects in patients with established cardiovascular disease. The treatment also showed comparable reductions in major adverse cardiovascular events and received FDA approval in June 2023 for primary cardiovascular prevention.

StudiuAVC și AITÎncredere bună21.06.2026

Clinical state and future directions of stem cell therapy in stroke rehabilitation

This comprehensive review examines stem cell therapies for stroke patients, including autologous bone marrow-derived cells administered via intravenous, intrathecal, or intracerebral routes at various post-stroke phases. Early-phase trials demonstrate safety and tolerability with some improvements in NIH Stroke Scale scores, though definitive clinical effectiveness remains unproven and additional research is needed.

StudiuAVC și AITÎncredere înaltă21.06.2026

Systematic Review and Meta-Analysis of Antithrombotic Therapy Delivery Within 48 Hours of Ischemic Stroke

This meta-analysis of 45 audits covering 1.18 million stroke patients found that 81.1% received antithrombotic therapy within 48 hours, falling below the 85% quality benchmark established by stroke care guidelines. Treatment delivery rates were comparable between high-income and low-to-middle-income countries, with improvements noted in studies published after 2008.

StudiuAVC și AITÎncredere înaltă21.06.2026

Comparison of American and European Guideline Recommendations for Diagnostic Workup and Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack

This study compares stroke diagnostic and secondary prevention recommendations between American Heart Association/American Stroke Association (AHA/ASA) and European Stroke Organization (ESO) guidelines, analyzing 63 ESO and 82 AHA/ASA recommendations across 7 key topics. While most recommendations are similar, the guidelines assign different levels of evidence quality to many recommendations, with notable discrepancies in high-level evidence classifications.

StudiuAVC și AITÎncredere bună21.06.2026

Non-alcoholic fatty liver disease as a predictor of recurrent ischemic stroke and transient ischemic attack in carotid atherosclerosis

This retrospective study of 742 patients with carotid atherosclerosis found that non-alcoholic fatty liver disease (NAFLD) is independently associated with increased risk of recurrent ischemic stroke or transient ischemic attack during follow-up. A combined predictive model incorporating NAFLD status, clinical variables, and carotid plaque characteristics demonstrated superior performance in identifying high-risk patients for secondary stroke events.

StudiuAVC și AITÎncredere bună21.06.2026

Ischemic stroke incidence following COVID-19 bivalent booster vaccination in adults 65 years and older

A retrospective cohort study examined ischemic stroke and transient ischemic attack cases within 21 days of COVID-19 bivalent Pfizer vaccination in Kaiser Permanente patients aged 65+, finding an incidence of 34.3 per 100,000. While a safety signal was detected requiring further investigation, the authors appropriately note that validation of any causal association between vaccination and stroke risk is needed before conclusions can be drawn.