Crize epileptice și managementul lor.
127 de articoleA study of 403 epileptic children who discontinued anti-seizure medication after ≥2 years seizure-free identified that 12.7% experienced seizure relapse, with highest rates in genetic (25%) and structural (14.9%) etiologies. Key predictors of relapse included diagnosis age >2 years, defined etiology, focal seizures, and rapid medication withdrawal (<3 months).
This review examines how p75 neurotrophin receptor (p75NTR) contributes to epilepsy development through altered neurotransmitter balance and increased pro-BDNF/p75NTR expression in brain cells. The authors synthesize current evidence on the mechanistic pathways linking p75NTR overexpression to epileptogenesis and seizure pathogenesis.
This case analysis examines a driver with longstanding epilepsy who caused a traffic accident during a seizure-induced state of profound consciousness disturbance, addressing how courts determine criminal responsibility in such situations. The authors argue for expanded legal frameworks requiring multidisciplinary medical evaluation and therapeutic rather than purely penal measures to prevent future incidents and minimize psychiatric complications.
This retrospective study evaluated lacosamide (LCM) monotherapy in 55 adult epilepsy patients, comparing those with (n=19) and without (n=36) psychiatric comorbidities over 6 months. Both groups achieved >80% seizure freedom with minimal psychiatric adverse effects (one case of irritability), and two patients with anxiety experienced symptom improvement, suggesting LCM is well-tolerated in epilepsy patients with pre-existing psychiatric conditions.
This meta-analysis of 25 observational studies (24,596 pregnancies) found that pregnant women with epilepsy who experience seizures have increased risks of caesarean delivery, peripartum depression, preterm birth, and small-for-gestational-age infants compared to those without seizures. The review also examined how socioeconomic factors may influence seizure control during pregnancy.
Hemispherotomy is a neurosurgical technique that disconnects one cerebral hemisphere to control severe, drug-resistant seizures in children following traumatic brain injury. This specialized intervention is considered when epilepsy originating from one hemisphere cannot be managed with medications, offering potential seizure control through anatomical brain disconnection rather than tissue removal.