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Tristețe persistentă, lipsa energiei și a motivației.

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StudiuDepresieÎncredere bună18.06.2026

The 'Discontinuity Hypothesis' of Depression in Later Life: Clinical and Research Implications

This narrative review challenges the assumption that depressed mood exists on a continuum with depressive disorders, proposing instead that in older adults, depressed mood may be an aging-related consequence of physical illness in people resilient to actual depressive disorders. The authors argue that differences in course, poor screening predictive value, and inconsistent dose-response relationships support reconceptualizing depression in later life, with implications for pharmacological treatment efficacy.

StudiuDepresieÎncredere bună18.06.2026

Digital Biomarkers in Major Depressive Disorder and Treatment-Resistant Depression: A Narrative Review

This narrative review examines digital biomarkers and wearable technologies used to predict diagnostic status, assess symptom severity, identify treatment response, and monitor real-world outcomes in major depressive disorder (MDD) and treatment-resistant depression (TRD). The analysis of 12 peer-reviewed studies from 2013-2023 shows that physiological, activity/sleep, and subjective data collected via wearable devices show promise in improving depression management given the current low remission rates.

StudiuDepresieÎncredere bună18.06.2026

Preventing recurrence of postpartum depression by regulating sleep

This review examines medication and psychotherapy approaches for preventing postpartum depression in women with prior mood disorders, finding contradictory results from prophylactic drug studies. The authors propose that addressing sleep loss and insomnia—common early symptoms in perinatal psychiatric disorders—may be a more effective prevention strategy than traditional antidepressant-only approaches.

StudiuDepresieÎncredere bună18.06.2026

Cariprazine augmentation in treatment-resistant depression: A case-series of patients failing previous atypical antipsychotic augmentation

This case-series documents ten patients with treatment-resistant unipolar depression who had failed conventional antidepressant monotherapy and initial augmentation with standard atypical antipsychotics (aripiprazole, risperidone, or brexpiprazole). The study explores switching to cariprazine as a second-line augmentation strategy, with seven of ten patients showing clinical improvement.

StudiuDepresieÎncredere bună18.06.2026

Sertraline Treatment of Depression with Psychotic Features in an Adolescent with Dystonia

A case report of a 17-year-old female with dystonia whose depressive and psychotic symptoms persisted despite dopaminergic treatment but improved after sertraline addition without motor symptom worsening. The authors emphasize that psychiatric disorders may be intrinsic to dystonia's neurobiology rather than purely secondary, highlighting the importance of early detection and integrated treatment approaches.

StudiuDepresieÎncredere bună17.06.2026

Neurofilament light chain plasma levels in major depressive disorder: a brief research report

This study measured plasma neurofilament light chain (NfL) levels using advanced SIMOA technology in 15 major depressive disorder patients and 15 healthy controls to investigate whether NfL is altered in depression. The researchers found no significant difference in NfL plasma levels between groups and no correlation with depression severity measures, though age showed positive correlation with NfL in both groups.

StudiuDepresieÎncredere bună17.06.2026

Targeting Divergent Pathways in the Nutritional Management of Depression

This narrative review examines nutritional approaches to depression management, focusing on nutrients with substantial scientific evidence including vitamin D, B vitamins, and omega-3 fatty acids. The paper synthesizes epidemiological data, mechanistic explanations, and intervention studies while positioning nutrition as a complementary strategy alongside pharmaceutical treatment.

StudiuDepresieÎncredere bună17.06.2026

Analgesics and Adjuvant Medications: Effects on Psychiatric Comorbidities in Complex Regional Pain Syndrome

This observational study of 1,029 CRPS patients examined how different pain medications affect psychiatric outcomes, finding no significant differences between opioid and non-opioid analgesics for depression or anxiety, but showing anticonvulsants were associated with higher risk of psychiatric comorbidities compared to antidepressants. The results suggest antidepressants may offer greater psychiatric benefits for CRPS patients while highlighting the need for individualized treatment planning.

StudiuDepresieÎncredere bună17.06.2026

Effects of Light Therapy in the Anxious-Depressive Clinic

Light therapy is an established therapeutic intervention studied for treating depression and anxiety symptoms in clinical settings. Research supports its use particularly for seasonal mood disorders, though effectiveness varies across conditions and patient populations.

StudiuDepresieÎncredere bună17.06.2026

Estradiol modulates resting-state connectivity in perimenopausal depression

A neuroimaging study examined how transdermal estradiol affects brain connectivity patterns in perimenopausal women with depression versus controls over three weeks. Results showed estradiol induced specific changes in connectivity between reward/emotion processing regions, suggesting a neural mechanism for hormone therapy's mood benefits in perimenopausal depression.

StudiuDepresieÎncredere bună17.06.2026

Recent advances in the synthesis of antidepressant derivatives: pharmacologic insights for mood disorders

This review examines emerging pharmacological targets and novel antidepressant compounds for treating major depressive disorder, focusing on their mechanisms of action and supporting evidence. While conventional antidepressants remain primary treatment, ongoing research explores new compounds showing promising results for treatment-resistant depression.

StudiuDepresieÎncredere bună17.06.2026

Comparison of Antidepressant Effectiveness in Preventing Psychiatric Rehospitalization: A Single-Center Retrospective Analysis

This retrospective study examined psychiatric readmission rates for adults with major depressive disorder based on which antidepressant medication they received at hospital discharge. Patients discharged on sertraline showed significantly lower 30-day readmission rates compared to other antidepressant treatments, though the small sample size limits generalizability.

StudiuDepresieÎncredere bună17.06.2026

Cotard's Delusion in Major Depressive Disorder With Psychotic Features: A Case Report

This case report describes a 44-year-old man with major depressive disorder and psychotic features who experienced Cotard's delusion (false belief that parts of his body were decaying or that he was dead). The patient showed limited response to various antidepressant-antipsychotic combinations but achieved substantial improvement with venlafaxine monotherapy, highlighting the need for further research into optimal pharmacological treatments for this rare condition.

StudiuDepresieÎncredere înaltă17.06.2026

Depression and Anxiety Management in Cirrhosis: Clinical Prevalence and Treatment Approaches

Depression and anxiety are significantly more common in cirrhosis patients than the general population, with prevalence increasing substantially over the past decade, and both conditions negatively impact quality of life and treatment outcomes. Management involves screening, pharmacological treatment with dose-adjusted antidepressants, psychotherapy, and multidisciplinary care approaches tailored to the patient's hepatic function.