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Demențe

Boala Alzheimer și alte forme de demență.

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StudiuDemențeÎncredere bună20.06.2026

The Vascular Hypothesis of Dementia, including Alzheimer's Disease, and Risk Factors for Vascular and Alzheimer's Dementia in African Populations

This work explores the vascular hypothesis as a mechanism underlying both Alzheimer's disease and vascular dementia, with particular attention to how cardiovascular risk factors contribute to dementia development. The research examines prevalence patterns and etiological factors specific to African populations, addressing potential disparities in dementia pathophysiology and risk profiles.

StudiuDemențeÎncredere bună20.06.2026

Sex Differences in Dementia with Lewy Bodies: Role of Alzheimer's Disease Biomarkers

This retrospective study of 310 DLB patients examined whether sex-related clinical differences are explained by Alzheimer's disease cerebrospinal fluid biomarkers. While AD co-pathology accounts for some sex differences (REM sleep disorder, cognitive scores), other features like parkinsonism appear driven by additional mechanisms independent of AD biology.

StudiuDemențeÎncredere înaltă20.06.2026

Inflammation as a Mediator of Air Pollution's Role in Alzheimer's Disease and Related Dementias

This study examined the relationship between air pollution exposure and cognitive decline in older adults, finding that exposure to fine particulate matter (PM₁₀) increases Alzheimer's disease risk, with inflammatory marker C-reactive protein mediating approximately 43% of this effect. Using genetic and observational data from over 7,000 Chinese participants, the research provides evidence that air pollution may causally contribute to dementia through inflammation-related pathways.

StudiuDemențeÎncredere înaltă20.06.2026

Body Weight Variability and Dementia Risk: A Systematic Review and Meta-Analysis

This meta-analysis of 16 cohort studies found that high body weight fluctuation is associated with increased risk of all-cause dementia, Alzheimer's disease, and vascular dementia, with hazard ratios ranging from 1.33 to 1.40 compared to stable weight. No significant association was found between weight variability and general cognitive decline, and evidence certainty was assessed using rigorous GRADE methodology.

StudiuDemențeÎncredere bună20.06.2026

Anti-Amyloid Drugs for Alzheimer's Disease: Considering the Role of Depression

This article examines how anti-amyloid monoclonal antibodies used to treat Alzheimer's disease may interact with or influence depression, a common comorbidity in elderly patients. The review discusses the neurobiological connections between amyloid pathology and mood disorders, and implications for treatment outcomes.