Autentificare
NeuroPsy InfoHubÎnțelege · Sprijin · ProgresCere sprijin
← Toate temele

Demențe

Boala Alzheimer și alte forme de demență.

73 de articole
← Toate secțiunile

Studii și știri

PublicToțiPentru oricineSpecialiști
VârstăToate vârsteleCopiiTineriAdulțiVârstnici
StudiuDemențeÎncredere înaltă19.06.2026

Validation of proper name recall decline with pTau217 as an early cognitive marker in at-risk cognitively unimpaired adults

This study validates that proper name recall from the Logical Memory task is sensitive to blood-based pTau217 levels, with participants showing higher pTau217 concentrating displaying steeper cognitive decline. APOE ε4 allele carriers with elevated pTau217 showed greater longitudinal decline, suggesting proper name recall may be a useful marker for detecting early cognitive changes in preclinical Alzheimer's disease.

StudiuDemențeÎncredere înaltă19.06.2026

Persistent Functional Impairment as a Preclinical Marker of Alzheimer's Disease: Advancing Dementia Risk Prediction

Research shows that persistent (not temporary) functional decline in cognitively normal older adults is a strong predictor of future cognitive decline and dementia development. The study proposes using functional trajectory monitoring as a practical, scalable biomarker for early dementia detection that complements cognitive testing and biomarkers.

StudiuDemențeÎncredere înaltă19.06.2026

Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum

This review examines diffusion magnetic resonance imaging (dMRI) findings across multiple dementia types, including Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, and primary progressive aphasia, identifying both shared and disease-specific patterns of white matter degeneration. Advanced dMRI methods such as NODDI and free-water imaging reveal microstructural alterations in specific brain tracts that correlate with each syndrome's clinical features and may improve early diagnosis and disease monitoring.

StudiuDemențeÎncredere bună19.06.2026

Epidemiological and clinical features of Alzheimer's disease in a memory clinic in Abidjan, Côte d'Ivoire

A retrospective hospital-based study of 36 Alzheimer's disease patients in sub-Saharan Africa found mean age 70.5 years, significant memory loss (89.2%), and bilateral hippocampal atrophy on MRI as the primary radiological finding. The study identified associations between disease severity and factors including age, education level, and different patterns of brain atrophy.

StudiuDemențeÎncredere înaltă19.06.2026

Advances in Anti-Dementia Therapies in Older Adults

Recent updates in dementia treatment include traditional medications (acetylcholinesterase inhibitors, memantine) now used off-label for vascular dementia, alongside newly approved amyloid-targeting monoclonal antibodies (lecanemab, donanemab) that show disease-modifying effects in early Alzheimer's disease but require careful monitoring for adverse effects. Non-pharmacological interventions such as regular exercise and multimodal lifestyle programs demonstrate cognitive benefits, while digital health applications and GLP-1 analogs show mixed or limited evidence.

StudiuDemențeÎncredere înaltă19.06.2026

Hippocampal GFAP in aging: Associations with Alzheimer's disease and LATE-NC pathologies and cognitive decline in older adults

This neuropathological study found that glial fibrillary acidic protein (GFAP) burden in the hippocampus is associated with both Alzheimer's disease-related pathologies (particularly neurofibrillary tangles and LATE-NC) and cognitive decline in older adults. Hippocampal GFAP appears to contribute to cognitive decline independently of these pathologies, suggesting it may be an important marker of neurodegeneration.

StudiuDemențeÎncredere bună19.06.2026

Clock Drawing Test as a Cognitive Decline Screening Tool in Brazilian Adults and Elderly: Diagnostic Performance Analysis

This study evaluated the Clock Drawing Test's ability to detect cognitive decline in 113 adults and older adults from Northeastern Brazil, examining its performance across different ages, education levels, and clinical diagnoses. Using established scoring methods and statistical analyses, the research assessed the test's sensitivity, specificity, and accuracy for identifying cognitive impairment and differentiating diagnostic conditions.