Prenatal Indomethacin Exposure Associated With Autism-Like Behavioral Changes Linked to Oxidative Stress and Altered Autophagy Signaling

This preclinical study investigated whether prenatal exposure to indomethacin (a COX inhibitor) induces autism-spectrum-relevant behaviors in rats, finding reduced sociability and motor performance alongside decreased prostaglandin signaling, increased oxidative stress, and glial activation. The findings suggest prenatal inhibition of prostaglandin synthesis may contribute to neurodevelopmental alterations through neuroinflammatory mechanisms.