Synbiotic supplementation with pigmented corn extract in drug-naïve children with ADHD: A randomised double-blind controlled trial

This double-blind RCT examined whether synbiotic supplementation enriched with pigmented corn extract improves behaviour, cognition, and brain function in 41 untreated children with ADHD over 3 months. The study found no significant differences between the enriched synbiotic and standard synbiotic groups across primary outcomes (fatty acids), microbiota composition, behavioral ratings, or neurophysiological markers.