Metformin as Adjunctive Treatment for Irritability in Children with Autism: A Randomized Controlled Trial

A 10-week double-blind trial tested metformin (500mg daily) combined with risperidone versus risperidone alone in 55 children with autism, measuring irritability and behavioral symptoms using standardized assessments. Metformin showed significant improvements in irritability and some behavioral subscales compared to placebo, with no safety concerns reported.