Efficacy of Anzeilax, a Smartphone-Based Digital Therapeutic for Generalized Anxiety Disorder: A Randomized Controlled Trial

A 10-week randomized controlled trial evaluated Anzeilax, an acceptance and commitment therapy-based digital app incorporating self-talk to enhance psychological flexibility, versus treatment as usual in 96 participants with generalized anxiety disorder. Primary and secondary outcomes measured anxiety symptoms, worry, and depression using validated clinical scales (GAD-7, BAI, PSWQ, HADS).