Anhedonia in Depressive Disorder and Schizophrenia: Causes, Diagnosis, and Treatment Overview

Anhedonia, the inability to experience pleasure, is a challenging symptom in major depressive disorder and schizophrenia involving dopaminergic system dysfunction. Treatment approaches include combination pharmacotherapy (glutamatergic agents, KOR antagonists, KCNQ activators), neurostimulation, and psychotherapy, with accurate component identification and reward system understanding being key to selecting effective interventions.