Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder

This review evaluates psilocybin's therapeutic potential for major depressive disorder by analyzing clinical studies from 2014-2024, examining its efficacy, safety, and mechanisms of action through serotonin receptor activity and neuroplasticity enhancement. The research highlights promising rapid and sustained symptom relief but emphasizes the need for larger studies, regulatory reform, and long-term safety data to fully establish psilocybin-assisted therapy as a viable treatment option.