Community Modeling Reveals Disrupted Gut Microbial Secretion in Autism Associated With Redox and Neurometabolic Alterations

This study applied computational metabolic modeling to gut microbiome data from autistic and non-autistic children, predicting altered secretion of neuroactive metabolites including increased GABA and reduced riboflavin. Microbiota transfer therapy shifted metabolic profiles toward non-autistic patterns and correlated with reduced autism severity, though the research remains mechanistic and correlational rather than proving causation.