Effects of nutritional supplementation on social impairment and behavioral dysregulation in autism spectrum disorder: a network meta-analysis

A network meta-analysis of 16 randomized controlled trials involving 736 children with ASD compared nutritional supplements (omega-3, vitamin D, probiotics, etc.) for effects on social functioning and behavioral symptoms. Omega-3 and vitamin D showed modest improvements in some measures compared to untreated controls, though relative efficacy among interventions remains incompletely characterized.