Allostatic Load as a Modifier of Neuropsychiatric Risk Following Traumatic Brain Injury

This cohort study examines whether pre-injury allostatic load (cumulative physiological burden from chronic stress) predicts post-TBI mortality and neuropsychiatric complications using data from the All of Us Research Program. The research uses validated biomarkers and clinical diagnostic codes to assess whether chronic stress exposure prior to injury influences TBI trajectory and outcomes.